The Biswal Laboratory Website

Publications

107. Biswal S, Thimmulappa R, and Harvey C. (2012) Experimental Therapeutics of Nrf2 as a Target for Prevention of Bacterial Exacerbations in COPD. Proc Am Thorac Soc. (in press)

106. Traore K, Zirkin B, Thimmulappa R, Biswal S, and Trush M. (2012) Up-regulation of TLR1, TLR2, TLR4 and IRAK2 expression during ML-1 cell differentiation to macrophages : Role in the potentiation of cellular responses to LPS and LTA. ISRN Oncology. (in press)

105. Harvey C, Thimmulappa R, Sethi S, Kong X, Yarmus L, Brown R, Feller-Kopman D, Wise R, and Biswal S. (2011) Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model. Science Transl Med 3(78):78ra32. PMID: 21490276

104. Malhotra D, Thimmulappa R, Mercado N, Ito K, Kombairaju P, Kumar S, Ma J, Feller-Kopman D, Wise R, Barnes P, and Biswal S. (2011) Denitrosylation of HDAC2 by Targeting Nrf2 Restores Glucocorticosteroid Sensitivity in Macrophages from COPD Patients. J Clin Invest. 121(11):4289-4302. PMID: 22005302

103. Merchant A, Singh A, Matsui W, and Biswal S. (2011) The redox-sensitive transcription factor, Nrf2, regulates murine hematopoietic stem cell survival independent of ROS levels. Blood. 118:6572-6579. PMID: 22039262

102. Kong X, Thimmulappa R, Craciun F, Harvey C, Singh A, Kombairaju P, Reddy SP, Remick D, and Biswal S. (2011) Enhancing Nrf2 Pathway by Disruption of Keap1 in Myeloid Leukocytes Protects Against Sepsis. Am J Respir Crit Care Med. 184:928-938. PMID: 21799073

101. Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, Tuder RM, and Armanios M. (2011) Telomere Length is a Determinant of Emphysema Susceptibility. Am J Respir Crit Care Med. 184:904-912. PMID: 21757622

100. Reddy N, Vegiraju S, Irving A, Paun B, Luzina I, Atamas S, Biswal S, Navas-Acien A, Mitzner W and Reddy S. (2011) Targeted deletion of jun/ap-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smoke-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol. 180(2):562-74.

99. Reddy NM, Potteti HR, Mariani TJ, Biswal S, and Reddy SP. (2011) Conditional Deletion of Nrf2 in Airway Epithelium Exacerbates Acute Lung Injury and Impairs the Resolution of Inflammation. Am J Respir Cell Mol Biol. 45(6):1161-8. PMID: 21659655

98. McGrath-Morrow SA, Lauer T, Collaco JM, Yee M, O’Reilly M, Mitzner W, Neptune E, Wise R, and Biswal S. (2011) Neonatal hyperoxia contributes additively to cigarette smoke-induced COPD changes in adult mice. Am J Respir Cell Mol Biol. 45(3):610-6. PMID: 21239606

97. Zhou W, Dowell D, Geraci M, Blackwell T, Collins R, Polosukhin V, Lawson W, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb D; Toki S, Morrow J, and Peebles, Jr. J. (2011) PGI Synthase Overexpression Protects Against Bleomycin-Induced Mortality and Is Associated with Increased Nqo 1 Expression. Am J Physiol Lung Cell Mol Physiol. 301(4):L615-L622. PMID: 21764988

96. Noel S, Saams J, Ong MJ, Breysse P, Diette G, Biswal S, and Matsui E. (2011) Opposing effects of nasal epithelial NQO1 and HO-1 expression on upper and lower airway symptoms in adolescents with asthma. J Allergy Clin Immunol 128(2):422-424.e3. PMID: 21531452

95. Pandey MK, Kumar S, Thimmulappa RK, Parmar VS, Biswal S, and Watterson AC. (2011) Design, Synthesis and Evaluation of Novel PEGylated Curcumin Analogs as Potent Nrf2 Activators in Human Bronchial Epithelial Cells. Eur J Pharm Sci 43(1-2):16-24. PMID: 21426935

94. Mercado N, Thimmulappa R, Thomas CM, Fenwick PS, Chana KK, Donnelly LE, Biswal S, Ito K, and Barnes PJ. (2011) Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun 406(2):292-8. PMID: 21320471

93. Kumar V, Kumar S, Hassan M, Wu H, Thimmulappa RK, Kumar A, Sharma SK, Parmar VS, Biswal S, and Malhotra SV. (2011) Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells. J Med Chem 54(12):4147-59. PMID: 21539383

92. Gao M, Singh A, Macri K, Reynolds C, Singhal V, Biswal S and Spannhake E. (2011) Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system. Respir Res 12(1):92. PMID: 21752292

91. Li Q, Singh, A, Biswal S, Askin F, and Gabrielson E. (2011) KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma. J Hum Genet 56(3):230-4. PMID: 21248763

90. McGrath-Morrow S, Malhotra D, Lauer T, Collaco JM, Mitzner W, Neptune E, Wise R, and Biswal S. (2011) Exposure to neonatal cigarette smoke causes durable lung changes but does not potentiate cigarette smoke-induced COPD in adult mice. Exp Lung Res 37(6):354-63. PMID: 21649527

89. Cui W, Ma J, Wang Y, and Biswal S. (2011) Plasma miRNA as Biomarkers for Assessment of Total-Body Radiation Exposure Dosimetry. PLoS ONE 6(8)e22988. PMID: 21857976

88. Wang B, Cao W, Biswal S, and Doré S. (2011) Carbon monoxide-activated nrf2 pathway leads to protection against permanent focal cerebral ischemia. Stroke 42(9):2605-10. PMID: 21852618

87. Jachak A, Lai SK, Hida K, Suk JS, Markovic N, Biswal S, Breysse PN, and Hanes J. (2011) Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus. Nanotoxicology (in press) PMID: 2180953

86. Malhotra S, Balwani S, Dhawan A, Singh BK, Kumar S, Thimmulappa R, Biswal S, Olsen CE, Van der Eycken E, Prasad AK, Ghosh B, and Parmar V. (2011) Synthesis and biological activity evaluation of N-protected isatin derivatives as inhibitors of ICAM-1 expression on human endothelial cells. Med Chem Comm 2:743-751.

85. Kumar S, Reddy C, Kumar A, Singh B, Kumar V, Malhotra S, Pandey M, Jain R, Thimmulappa R, Sharma S, Prasad A, Biswal S, Van der Eycken E, DePass A, Malhotra SV, Ghosh B, and Parmar V. (2011) Arylalkyl Ketones, Benzophenones, Desoxybenzoins and Chalcones Inhibit TNF-? Induced Expression of ICAM-1: Structure-Activity Analysis. Arch Pharm. (in press)

84. Kumar S, Singh B, Arya P, Malhotra S, Tummulappa R, Prasad A, Van der Eycken E, Olsen C, DePass A, Biswal S, Parmar V, and Ghosh B. (2011) Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells. Eur J Med Chem 54(12):4147-59. PMID: 21955679

83. Singh A, Wu H, Zhang P, Happel C, Ma J, and Biswal S. (2010) Expression of ABCG2 (BCRP), a Marker of Stem Cells, is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemo-resistance Phenotype. Mol Cancer Ther 9(8):2365-76. PMID: 20682644

82. Wakabayashi N, Shin S, Slocum S, Agoston ES, Wakabayashi J, Kwak MK, Misra V, Biswal S, Yamamoto M, and Kensler TW. (2010) Regulation of Notch1 signaling by Nrf2: implications for tissue regeneration. Sci Signal 3(130):ra52. PMID: 20628156

81. Solis L, Behrens C, Dong W, Suraokar M, Ozburn N, Moran C, Corvalan A, Biswal S, Swisher S, Bekele BN, Minna J, Stewart D, and Wistuba I. (2010) Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features. Clin Cancer Res 16(14):3743-53. PMID: 20534738

80. Kong X, Thimmulappa R, Kombairaju P, and Biswal S. (2010) NADPH Oxidase-Dependent Reactive Oxygen Species Mediate Amplified TLR4 Signaling and Sepsis-Induced Mortality in Nrf2-deficient Mice. J Immunol 185(1):569-77. PMID: 20511556

79. Shah ZA, Li RC, Ahmad AS, Kensler TW, Yamamoto M, Biswal S, and Doré S. (2010) The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway. J Cereb Blood Flow Metab 30(12):1951-61. PMID: 20442725

78. Yoshida T, Mett I, Bhunia A, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa R, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro S, Petrache, Biswal S, Feinstein E, and Tuder R. (2010) RTP801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke induced pulmonary injury and emphysema. Nat Med 16(7):767-73. PMID: 20473305

77. Cano M, Thimmalappula R, Fujihara M, Nagai N, Sporn M, Wang AL, Neufeld AH, Biswal S, and Handa JT. (2010) Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and age-related Macular Degeneration. Vision Res. 50(7):652-64. PMID: 19703486

76. Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, Shyr C, Wakabayashi N, Kensler T, Wasserman W, and Biswal S. (2010) Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res. 38(17):5718-34. PMID: 20460467

75. Singh A, Bodas M, Wakabayashi N, Bunz F, and Biswal S. (2010) Gain of Nrf2 function in Non-Small Cell Lung Cancer Cells Confers Radioresistance. Antioxid. Redox. Signal. 13(11):1627-37. PMID: 20446773

74. Zhang P, Singh A, Yegnasubramanian S, Eposi D, Kombairaju P, Bodas M, Wu H, Bova SG, and Biswal S. (2010) Loss of Keap1 Function in Prostate Cancer Cells Causes Chemo- and Radio-resistance and Promotes Tumor Growth. Mol Cancer Ther 9(2):336-46. PMID: 20124447

73. Malhotra D, Thimmulappa R, Vij N, Sussan T, Merali S, Zhang L, Kelsen S, Myers A, Wise R, Tuder RM, and Biswal S. (2009) Heightened endoplasmic reticulum stress in COPD lungs: the role of Nrf2 regulated proteasomal activity. Am J Respir Crit Care Med. 180:1196-1207. PMID: 19797762

72. Rangasamy T, Williams MA, Bauer S, Trush M, Emo J, Georas N, and Biswal S. (2009) Nrf2 Inhibits the Maturation of Murine Dendritic Cells by the Ragweed Allergen. Am. J. Respir. Cell Mol Biol 43(3):276-85. PMID: 19805484

71. Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, and Biswal S. (2009) Targeting Nrf2 with the Triterpenoid CDDO-Imidazolide Attenuates Cigarette Smoke-Induced Emphysema and Cardiac Dysfunction in Mice. Proc. Natl. Acad. Sci. 106(1):250-5. PMID: 19104057

70. Singh A, Ling G, Suhasini AN, Zhang P, Yamamoto M, Navas-Acien A, Cosgrove G, Tuder RM, Kensler TW, Watson WH, Biswal S. (2009) Nrf2 Dependent Sulfiredoxin-1 Expression Protects Against Cigarette Smoke induced Oxidative Stress in Lungs. Free Radic Biol Med. 1;46(3):376-86. PMID: 19027064

69. Harvey CJ, Thimmulappa RK, Singh A, Blake DH, Ling G, Wakabayashi N, Fujii J, Myers AC, and Biswal S. (2009) Nrf2 regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress. Free Radic Biol Med 46(4)443-53. PMID: 19028565

68. Rangasamy T, Misra V, Zhen L, Tankersley CG, Tuder, RM, and Biswal, S. (2009) Cigarette Smoke-Induced Emphysema in A/J mice is Associated with Pulmonary Oxidative Stress, Apoptosis of lung Cells, and Global Alterations in Gene Expression. Amer. J. Physiol. Lung Cell. Mol. Physiol. 296(6):L888-900. PMID: 19286929

67. Blake DJ, Singh A, Kombairaju P, Malhotra D, Mariani TJ, Tuder RM, and Biswal S. (2009) Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. Am J Respir Cell Mol Biol 42(5):524-36. PMID: 19520915

66. An SS, Kim J, Ahn K, Trepat X, Drake KJ, Kumar S, Ling G, Purington C, Rangasamy T, Kensler TW, Mitzner W, Fredberg JJ, and Biswal S. (2009) Cell stiffness, contractile stress and the role of extracellular matrix. Biochem. Biophys. Res. Comm. 382(4):697-703. PMID: 19327344

65. Norihiro Nagai,N., Thimmulappa,R.K., Cano,M., Fujihara,M., Izumi-Nagai,K., Kong, X., Sporn, M.B., Kensler, T.W., Biswal,S. Handa, J.T. (2009) Nrf2 is a Critical Modulator of the Innate Immune Response in a Model of Uveitis Free Radic Biol Med. 47(3):300-6. PMID: 19410644

64. McGrath-Morrow S, Lauer T, Yee M, Neptune E, Podowski M, Thimmulappa R, OReilly M, and Biswal S. (2009) Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol. 296(4):L565-73. PMID: 19151108

63. Podowski M, Calvi CL, Cheadle C, Tuder RM, Biswal S, and Neptune ER. (2009) Complex integration of matrix, apoptosis, and oxidative stress in genetic emphysema. Am. J. Pathol. 175(1):84-96. PMID: 19541933

62. Le A, Zielinski R, He C, Crow MT, Biswal S, Tuder RM, and Becker PM. (2009) Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema. Am J Respir Crit Care Med. 180(5):396-406. PMID: 19520907

61. Bivalacqua TJ, Sussan TE, Gebska MA, Strong TD, Berkowitz DE, Biswal S, Burnett AL, Champion HC. (2009) Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in mouse model of secondhand smoke induced erectile dysfunction. J. Urol 181(2):899-906. PMID: 19095260

60. Sussan TE, Jun J, Thimmulappa R, Bedja D, Antero M, Gabrielson KL, Polotsky VY, Biswal S. (2008) Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice. PLoS ONE. 3(11):e3791. PMID: 19023427

59. Singh A, Boldin-Adamsky S ,Thimmulappa RK, Rath SK, Ashush H, Coulter J, Blackford A, Goodman SN, Bunz F, Watson WH, Gabrielson E, Feinstein E, and Biswal S.(2008) RNAi-mediated silencing of nuclear factor erythroid-2-related factor gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res. 68:(19):7975-84. PMID: 18829555

58. Malhotra D, Thimmulappa RK, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S. (2008) Decline in NRF2 regulated antioxidants in COPD lungs due to loss of its positive regulator DJ-1. Am J Respir Crit Care Med. 178(6):592-604. PMID: 18556627

57. Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S, Georas SN. (2008) Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. J Immunol. 181(7):4545-59. PMID: 18802057

56. Taylor RC, Acquaah-Mensah G, Singhal M, Malhotra D, Biswal S. (2008) Network Inference Algorithms Elucidate Nrf2 Regulation of Mouse Lung Oxidative Stress. PLoS Comp Biol. 4(8):e1000166. PMID: 18769717

55. Thimmulappa RK, Rangasamy T, Alam J, Biswal S. (2008) Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA Adducts in lungs. Med. Chem. 4(5):473--81. PMID: 18782044

54. Moens AL, Takimoto E, Tocchetti CG, Chakir K, Bedja D, Cormaci G, Ketner EA, Majmudar M, Gabrielson K, Halushka MK, Mitchell JB, Biswal S, Channon KM, Wolin MS, Alp NJ, Paolocci N, Champion HC, Kass DA. (2008) Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. Circulation. 117(20):2626-36. PMID: 18474817

53. Saleem S, Zhuang H, Biswal S, Christen Y, Dor S. (2008) Ginkgo Biloba Extract Neuroprotective Action Is Dependent on Heme Oxygenase 1 in Ischemic Reperfusion Brain Injury. Stroke. 39(12):3389-96. PMID: 18845796

52. Fujihara M, Nagai N, Sussan TE, Biswal S, Handa JT. (2008) Chronic Cigarette Smoke Causes Oxidative Damage and Apoptosis to Retinal Pigmented Epithelial Cells in Mice. PLoS ONE 3(9): e3119. PMID: 18769672

51. Huang K, Rabold R, Abston E, Schofield B, Misra V, Galzicka E, Lee H, Biswal S, Mitzner W, Tankersley CG. (2008) Effects of Leptin Deficiency on Postnatal Lung Development in Mice. J Appl Physiol. 105(1):249-59. PMID: 18467551

50. Traore, K, Sharma, R, Thimmulappa RK, Watson WH, Biswal S, Trush MA. (2008) Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: Role in signaling TPA-induced growth arrest in ML-1 cells. J Cell Physiol. 216(1):276-85. PMID: 18270969

49. Malhotra S, Shakya G, Kumar A, Vanhoecke BW, Cholli AL, Raj HG, Saso L, Ghosh B, Bracke ME, Prasad AK, Biswal S, and Parmar VS. (2008) Antioxidant, Antiinflammatory and Antiinvasive Activities of Biopolyphenolics. ARKIVOC (vi) 119-139.

48. McGrath-Morrow S, Rangasamy T, Cho C, Sussan T, Neptune E, Wise R, Tuder RM, Biswal S. (2008) Impaired Lung Homeostasis in Neonatal Mice Exposed to Cigarette Smoke. Am J Respir Cell Mol Biol. 38(4):393-400. PMID: 17975176

47. Kensler TW, Wakabayaski N, Biswal S. (2007) Cell survival resonses to Environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 47:89-116. PMID: 16968214

46. Misra V, Lee H, Singh A, Huang K, Thimmulappa RK, Mitzner W, Biswal S, and Tankersley CG. (2007) Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes. Physiol Genomics 31(3):429-40. PMID: 17726092

45. Papaiahgari S, Yerrapureddy A, Reddy SR, Reddy NM, Dodd-O JM, Crow MT, Grigoryev DN, Barnes K, Tuder RM, Yamamoto M, Kensler TW, Biswal S, Mitzner W, Hassoun PM, Reddy SP. (2007) Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med. 176(12):1222-35. PMID: 17901416

44. Biswal S, and Remick DG. (2007) Sepsis: Redox Mechanisms and Therapeutic Opportunities. Antioxid Redox Signal 9(11):1959-62. PMID: 17711390

43. Thimmulappa R, Fuchs R, Malhotra D, Scollick C, Traore K, Bream J, Trush M, Liby K, Sporn MB, Kensler T, and Biswal S. (2007) Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxid Redox Signal; 9(11):1963-70. PMID: 17822364

42. Shin S, Wakabayashi N, Misra V, Biswal S, Lee GW, Agoston ES, Yamamoto M, and Kensler TW. (2007) Nrf2 modulates AHR signaling: influence on adipogenesis. Mol Cell Biol; 27(20):7188-97. PMID: 17709388

41. Reddy NM, Kleeberger SR, Cho HY, Yamamoto M, Kensler TW, Biswal S, Reddy SP. (2007) Deficiency in Nrf2-GSH Signaling Impairs Type II Cell Growth and Enhances Sensitivity to Oxidants. Am J Respir Cell Mol Biol. 37(1):3-8. PMID: 17413030

40. Rulli SJ Jr, Hibbert CS, Mirro J, Pederson T, Biswal S, Rein A. (2007) Selective and non-selective packaging of cellular RNAs in retrovirus particles. J Virol. 81(12):6623-31. PMID: 17392359

39. Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, and Dore S. (2007) Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. Neuroscience 147(1):53-59. PMID: 17507167

38. Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW , Yamamoto M, Biswal S, and Dore S. (2007) Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radic Biol Med 43(3):408-14. PMID: 17602956

37. Huang K, Rabold R, Schofield B, Mitzner W, Lee H, Biswal S, Tankersley CG. (2007) Variation in senescent-dependent lung changes in inbred mouse strains. J Appl Physiol. 102(4):1632-9. PMID: 17218422

36. Balbir A, Lee H, Okumura M, Biswal S, Fitzgerald RS, Shirahata M. (2007) A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Am J Physiol Lung Cell Mol Physiol. 292(3):L704-15. PMID: 17098806

35. Manna SK, Rangasamy T, Wise K, Sarkar S, Shishodia S, Biswal S, and Ramesh GT. (2006) Long term environmental tobacco smoke activates nuclear transcription factor-kappa B, activator protein-1, and stress responsive kinases in mouse brain. Biochem Pharmacol 71(11):1602-9. PMID: 16569398

34. Thimmulappa RK, Scollick C, Trarore K, Yates M, Trush MA, Liby KT, Spoorn M, Yamamoto M, Kensler TW and Biswal S. (2006) Nrf2 dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun 351(4):883-889. PMID: 17097057

33. Thimmulappa RK, Lee H, Rangasamy T, Kensler TW, Yamamoto M, Reddy SP, and Biswal S. (2006) Nrf2 is a critical regulator of innate immune response and survival during experimental sepsis. J. Clin. Invest. 116(4):984-995. PMID: 16585964

32. Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman, JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S. (2006) Dysfunctional KEAP1 Nrf2 Interaction in Non-Small-Cell Lung Cancer. PLoS Medicine 3(10): e420. PMID: 17020408

31. Singh A, Rangasamy T, Thimmulappa RK, Lee H, Osburn WO, Brigelius-Flohe R, Kensler TW, Yamamoto M, Biswal S. (2006) Glutathione Peroxidase 2, the Major Cigarette smoke-inducible Isoform of GPX in Lungs is Regulated by Nrf2. Am J Respir Cell Mol Biol 35(6):639-50. PMID: 16794261

30. Tuder RM, Yoshida T, Fijalkowka I, Biswal S, Petrache I. (2006) Role of lung maintenance program in the heterogeneity of lung destruction in emphysema. Proc Am Thorac Soc. 3(8):673-9. PMID: 17065372

29. Biswal S, Rangasamy T, Tuder RM. (2006) Modifier Role of Nrf2 in Cigarette Smoke-induced Emphysema. Proc Am Thorac Soc 3:543a.

28. Yoshida T, Rangasamy T, Biswal S, Petrache I, Mett I. et al. (2006) Role of RTP801, a suppressor of the mTOR Pathway, in Cigarette Smoke-induced Pulmonary Injury in Mice. Proc Am Thorac Soc 3:551a-2.

27. Osburn, WO, Wakabayashi N, Misra V, Nilles T, Biswal S, Trush MA, Kensler, TW. (2006) Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Arch Biochem Biophys. 454(1):7-15. PMID: 16962985

26. Mensah GK, Misra V, Biswal S. (2006) Ethanol Sensitivity: A Central Role for CREB Transcription Regulation in the Cerebellum. BMC Genomics 7(1):308. PMID: 17147806

25. Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN and Biswal S. (2005) Disruption of Nrf2 Enhances susceptibility to Severe Airway Inflammation and Asthma in Mice. J. Exp. Med. 202(1):47-59. PMID: 15998787

24. Tian J, Ishibashi K, Ishibashi K, Reiser K, Grebe R, Biswal S, Gehlbach P, Handa JT. (2005) Advanced Glycation Endproduct-Induced Aging of the Retinal Pigment Epithelium and Choroid: A Comprehensive Transcriptional Response. Proc Natl Acad Sci. 102(33):11846-51. PMID: 16081535

23. Chen H, Rubin E, Zhang H, Chung S, Jie CC, Garrett E, Biswal S, Sukumar S. (2005) Identification of transcriptional targets of HOXA5. J Biol Chem. 280(19):19373-80. PMID: 15757903

22. Irizarry R, Warren D, Spencer F, Kim IF, Biswal S, Frank BC, Gabrielson E, Garcia JGN, Geoghegan J, Germino G, Griffin C, Hilmer SC, Hoffman E, Jedlicka AE, Kawasaki E, Martinez-Murillo F, Morsberger L, Lee H, Petersen D, Quackenbush J, S15520857cott A, Wilson M, Yang Y, Ye SQ, Yu W. (2005) Multiple-laboratory comparisons of microarray platforms. Nature Methods. 2(5):345-50. PMID: 15846361

21. Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma S, Kensler TW, Yamamoto M, Petrache I, Tuder RM and Biswal S. (2004) Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice, J. Clin. Invest. 114(9):1248-1259. PMID: 15520857

20. Biswal S, Maxwell T, Rangasamy T, Kehrer JP. (2003) Modulation of benzo[a]pyrene-induced p53 DNA activity by acrolein. Carcinogenesis, 24(80):1401-1406. PMID: 12807757

19. Srisuma S, Biswal S, Mitzner WA, Gallagher SJ, Mai KH and Wagner EM. (2003) Identification of genes promoting angiogenesis in mouse lung by transcriptional profiling. Am J Respir Cell Mol Biol. 29(2):172-179. PMID: 12600816

18. Wu XL, Biswal S and Kehrer JP (2003) Roles of 5-lipoxygenase activating protein in cell proliferation and apoptosis, Cell Biology and Toxicology, 19(3):135-43. PMID: 12945742

17. Thimmulappa RK, Mai KH, Srisuma S, Kensler TW Yamamoto M and Biswal S. (2002) Identification of Nrf2 Regulated Genes Induced by the Chemopreventive Agent Sulforaphane by Oligonucleotide Microarray. Cancer Res. 62(18):5196-5203. PMID: 12234984

16. Rangasamy T, Rajesh Kumar T, Mai KH and Biswal S. (2002) Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells. Toxicol Lett, 132(1):27- 36. PMID: 12084617

15. Biswal SS, Mensah GK, Datta K, Wu, XL and Kehrer JP. (2002) Inhibition of cell proliferation and AP-1 activity by acrolein in human A549 lung adenocarcinoma cells due to thiol imbalance and covalent modifications Chem. Res. Toxicol.15(2):180-186. PMID: 11849044

14. Biswal SS, Datta K and Kehrer JP. (2001) Association between bcl-xL and 5-lipoxygenase activating protein (FLAP) levels in IL-3 dependent FL5.12 cells Toxicology-160(1-3):97-103. PMID: 11246129

13. Kehrer JP, Biswal SS, Thuillier P, Datta K, Fischer S and Vanden Heuvel JP. (2001) Inhibition of Peroxisome Proliferator Activated Receptor alpha(PPARa) by MK886. Biochem. J. 356 (3) 899-906. PMID: 11389700

12. Datta K, Kern JC, Biswal SS and Kehrer JP. (2001) Proteolytic Loss of bcl-x(L) in FL5.12 Cells Undergoing Apoptosis Induced by MK886. Toxicol Appl Pharmacol 174(3):273-281. PMID: 11485388

11. Kehrer JP and Biswal SS. (2000) The molecular effects of acrolein. Toxicol. Sci. 57(1), 6-15. PMID: 10966506

10. Biswal SS, Datta K, Acquaah-Mensah GK and Kehrer JP. (2000) Changes in ceramide sphingomyelin and p53 following fludarabine treatment of human chronic B-cell leukemia cells. Toxicology. 154(1-3): 45-53. PM ID: 11118669

9. Biswal SS, Datta K, Shaw SD, Feng X, Robertson JD and Kehrer JP. (2000) Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells Toxicol. Sci. 53(1):77-83. PMID: 10653524

8. Horton ND, Biswal SS, Corrigan LL, Bratta J and Kehrer JP. (1999) Acrolein causes Inhibitor kB independent decreases in Nuclear factor-kB activation in human lung adenocarcinoma (A549) cells. J. Biol. Chem. 274(14):9200-9206. PMID: 10092592

7. Datta K, Biswal SS, Kehrer JP. (1999) The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP. Biochem. J. 340(2):371-375. PMID: 10333477

6. Robertson JD, Datta K, Biswal SS and Kehrer JP. (1999) HSP70 antisense oligomer enhances proteasome inhibitor-induced apoptosis. Biochem. J. 344(2):477-485. PMID: 10567231

5. Datta K, Biswal SS, Xu J, Towndrow KM, Feng X and Kehrer JP. (1998) A relationship between 5 lipoxygenase activating protein (FLAP) and bcl-xL expression in murine pro B-lymphocytic FL5.12 cells. J. Biol. Chem. 273(43): 28163-28169. PMID: 9774436

4. Ahn YT, Wu XL, Biswal SS, Velmurugan S, Volkert FC, and Jayaram M. (1997) The 2 um-plasmid-encoded Rep1 and Rep2 proteins interact with each other and colocalize to the Saccharomyces cerevisiae nucleus. J Bacteriol 179(23): 7497-506. PMID: 9393716

3. Biswas S, Bhelwa A, Itoop A, Biswal S and Nath N. (1994) In vitro effect of a diabetic serum factor on generation of superoxide free radical, its quenching ability and lysosomal degranulation in normal polymorphonuclear leucocytes. Ind J. Clin Biochem. 9: 3-8.

2. Biswas S, Bhelwa A, Itoop A, Biswal S and Nath N. (1994) Effect of diabetic serum factor on polymorphonuclear leukocyte membrane hydrophobicity and particle internalization. Ind J Clin Biochem 9 :9-15.

1. Nath N, Biswas S, Bhelwa A, Itoop A and Biswal S. (1993) Plausible involvement of a diabetic serum factor in neutrophil membrane pathology. Ind J Biochem Biophys 30(4): 244-246. PMID: 8276428